News Updates
Revolutionizing bone defect healing: the power of mesenchymal stem cells as seeds
Bone defects can arise from trauma or pathological factors, resulting in compromised bone integrity and the loss or absence of bone tissue. As we are all aware, repairing bone defects is a core problem in bone tissue engineering.
Hyaluronic acid, bone marrow aspirate concentrate provide long-term cartilage augmentation
Published results showed positive long-term clinical and functional outcomes for patients with knee chondral defects who underwent one-step cartilage repair with a hyaluronic acid-based scaffold and bone marrow aspirate concentrate graft.
Stem cells in orthopaedics and sports injuries: A comprehensive review and future research directions
With possible treatments for a variety of musculoskeletal disorders, stem cell therapy has become a highly promising field in orthopaedics. By utilizing the body's natural ability to heal, stem cell treatment provides a regenerative method for repairing and regenerating damaged tissues.
LINC01133 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by upregulating CTNNB1 by acting as a sponge for miR-214-3p
Marrow mesenchymal stem cell (MSC) dysfunction is associated with the pathogenesis of OP. MSCs are widely distributed in various organs and tissues and are the preferred cell type for bone regeneration. Among adult stem cells, bone marrow mesenchymal stem cells (BMSCs) are considered the most suitable option for bone tissue engineering due to their ability to self-renew, high differentiation potential, and low immunogenicity.
Microfragmented adipose tissue injections for knee OA may reduce pain, improve function
Published results showed microfragmented adipose tissue injections may yield clinically significant improvements for knee osteoarthritis pain, as well as improved function, compared with a saline control injection.
Mechanisms of treatment effects using allogeneic, umbilical cord-derived mesenchymal stromal stem cells (MSCs) in knee osteoarthritis: a pharmacological clinical study protocol
Knee osteoarthritis (KOA) presents a prevalent orthopedic condition causing substantial impairment in the quality of life and imposing a significant societal and economic burden. Mesenchymal stromal/stem cells (MSCs), known for their regenerative properties and immunomodulatory effects, have emerged as a promising therapeutic avenue in regenerative medicine. Despite MSCs' therapeutic potential, their precise mechanisms of action in KOA remain underexplored.
Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group
Injectable biologics have not only been described and developed to treat dermal wounds, cardiovascular disease, and cancer, but have also been reported to treat chronic pain conditions. Despite emerging evidence supporting regenerative medicine therapy for pain, many aspects remain controversial.
