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Modified Mesenchymal stem cell, platelet-rich plasma, and hyaluronic acid intervention in early stage osteoarthritis: A systematic review, meta-analysis, and meta-regression of arthroscopic-guided intra-articular approaches

Source: PubMed

Mesenchymal stem cells (MSCs) hold promise for osteoarthritis (OA) treatment, potentially enhanced by combining them with platelet-rich plasma (PRP) and hyaluronic acid (HA). This study aimed to assess the synergy of MSCs, PRP, and varying HA doses, and determine optimal MSC sources to treat early-stage OA in the perspective of Lysholm score, VAS Score, KSS score, and WOMAC score.

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  • American Orthopaedic Society for Sports Medicine
  • American Association of Nurse Anesthesiology
  • RYC Orthopedics
  • American Academy of Orthopaedic Surgeons
  • International Society for Hip Arthroscopy
  • Kerlan Jobe Orthopaedic Clinic
  • NYU Langone Medical Center
  • American Board of Orthopaedic Surgery
  • Yale University
  • OrthoEnglewood