Rotator cuff injury is a common upper extremity musculoskeletal disease that may lead to persistent pain and functional impairment. Despite the clinical outcomes of the surgical procedures being satisfactory, the repair of the rotator cuff remains problematic, such as through failure of healing, adhesion formation, and fatty infiltration. Stem cells have high proliferation, strong paracrine action, and multiple differentiation potential, which promote tendon remodeling and fibrocartilage formation and increase biomechanical strength.
Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration.
Source: Springer Link
Although autologous sources are promising, there is a wide range of limitations with the treatment, including the lack of randomized controlled studies for orthopaedic conditions, donor site morbidity, and highly variable outcomes for patients. Allogenic sources bypass some of these shortcomings and are a promising source for orthopaedic regenerative medicine applications.
Repeated leukocyte-poor platelet-rich plasma injections during and after double-row suture-bridge arthroscopic rotator cuff repair may reduce the retear rate and improve Goutallier grade and clinical outcomes, according to study results.
Published results showed intraoperative injection of autologous microfragmented adipose tissue may safely and effectively improve short-term clinical and functional outcomes after single-row arthroscopic rotator cuff repair.
Source: Future Medicine
The aim of this study was to assess the benefit of stem cell therapy in the treatment of mild to severe knee osteoarthritis.
A variety of regenerative therapies, including intraarticularly applied hemo-components and cell-based therapies are currently in clinical development and are, in part, in clinical use. Such therapies face several practical opportunities and challenges and could reduce the health care burden, in part by replacing traditional drug therapies and highly invasive surgical interventions with smarter and less invasive treatments.